5/6/2025
Last update
5/6/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Oregano Oil (Origanum vulgare) min. 55% Carvacrol)
0.2 ml / 181 mg
**
Ginger Oil (Zingiber officinale)
0.02 ml / 17.6 mg
**
Fennel Oil (Foeniculum vulgare)
0.02 ml / 19.3 mg
**
Top Medical Research Studies
8
We set out to investigate how oregano, specifically its extract, impacts lung cancer cells. Using a method that combined the aqueous extract of Origanum vulgare—commonly known as oregano—with silver nitrate, we were able to create silver nanoparticles. These nanoparticles were carefully analyzed using various scientific techniques, revealing that they had a spherical shape and an average size of about 136 nanometers.
The findings highlighted that these green synthesized silver nanoparticles were effective in inhibiting certain human pathogens. More importantly, they showed a dose-dependent response against the A549 cell line, a common model for studying lung cancer. Specifically, we noted an LD50 value of 100 micrograms per milliliter, indicating that the nanoparticles from oregano extract have promising anticancer properties.
Overall, this study showcases that oregano not only has potential in combating bacteria but may also play a role in the fight against lung cancer. This opens up exciting avenues for future research on natural remedies in cancer treatment.
The findings highlighted that these green synthesized silver nanoparticles were effective in inhibiting certain human pathogens. More importantly, they showed a dose-dependent response against the A549 cell line, a common model for studying lung cancer. Specifically, we noted an LD50 value of 100 micrograms per milliliter, indicating that the nanoparticles from oregano extract have promising anticancer properties.
Overall, this study showcases that oregano not only has potential in combating bacteria but may also play a role in the fight against lung cancer. This opens up exciting avenues for future research on natural remedies in cancer treatment.
Read More
9
We explored the anticancer potential of Origanum majorana essential oil (OMEO) on non-small cell lung cancer (NSCLC) using two significant human cancer cell lines: A549 and LNM35. Through a series of pre-clinical experiments, we observed that OMEO significantly reduced the viability of these cancer cells and inhibited their colony growth in a way that depends on the concentration used.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
Read More
8
We investigated how the methanol extract of Origanum syriacum, commonly known as oregano, affects lung cancer cells, particularly A549 cells. Our study aimed to understand whether this natural extract could suppress cell growth and induce programmed cell death, or apoptosis, which is crucial in targeting cancer cells.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
Read More
Most Useful Reviews
6
Good protective effects
4 people found this helpful
Strong and concentrated! Exceptional quality! The active ingredient is potent; I take one capsule twice daily after meals. The flavour of oregano is robust. This supplement is intended to regulate intestinal flora, and I believe it also has a beneficial effect on the lungs, offering protection against inflammation. I highly recommend it. The capsules are small in size.
Read More
7.5
Reduces lung infection
42 people found this helpful
Fun fact: The ancient Greeks used Oregano oil as an antidote! The manufacturer recommends 1 softgel 1–3 times daily. Oregano is an effective natural antibiotic. During my illness, my husband and I took numerous IHERB supplements, but Oregano twice daily was essential! Combined with other treatments, it prevented the virus from infecting my lungs, resulting in a "mild form" of the disease. It can sometimes cause belching, but that doesn't happen constantly. Even children can swallow the small gelatine capsules. I suggest starting Oregano in autumn or winter; it has helped our family immensely!
Read More
7.5
Skin and digestion improved
18 people found this helpful
Extraordinary!!! High-quality products from NOW FOODS contain oregano, ginger, and fennel oils. I’ve shared this with my 12-year-old. This oil has antiviral, antifungal, antibacterial, anti-cancer, and anti-inflammatory properties. We began taking oregano oil together as a family due to the recent wave of coronavirus. The kids have improved digestion, skin condition, and feel lighter.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
- All Researches
9
We explored the anticancer potential of Origanum majorana essential oil (OMEO) on non-small cell lung cancer (NSCLC) using two significant human cancer cell lines: A549 and LNM35. Through a series of pre-clinical experiments, we observed that OMEO significantly reduced the viability of these cancer cells and inhibited their colony growth in a way that depends on the concentration used.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
Read More
9
Carvacrol inhibits lung cancer growth
We explored how carvacrol, the main component found in oregano, impacts a specific type of lung cancer known as non-small cell lung cancer (NSCLC), particularly using the A549 cell line for our experiments. Carvacrol is well-known for its various health benefits, which include antibacterial and antioxidant effects. In our study, we incubated A549 cells with different concentrations of carvacrol and observed its effects on cell health and growth.
Our observations revealed that as we increased the dosage of carvacrol, the number of living cells decreased significantly. Not only did we notice a reduction in cell count, but we also saw marked changes in cell shape and structure, indicating physical degeneration. Under light microscopy, the treated cells demonstrated signs of distress, such as detachment from the surface, rounding, and irregular shapes.
The findings show that carvacrol can effectively inhibit cell growth in lung cancer cells. While this study highlights the potential of carvacrol derived from oregano in combating NSCLC, we should note that it does not specifically isolate the effects of oregano itself. Thus, while carvacrol's influence is significant, we must remain cautious about broadening these results to the wider effects of oregano as a whole.
Our observations revealed that as we increased the dosage of carvacrol, the number of living cells decreased significantly. Not only did we notice a reduction in cell count, but we also saw marked changes in cell shape and structure, indicating physical degeneration. Under light microscopy, the treated cells demonstrated signs of distress, such as detachment from the surface, rounding, and irregular shapes.
The findings show that carvacrol can effectively inhibit cell growth in lung cancer cells. While this study highlights the potential of carvacrol derived from oregano in combating NSCLC, we should note that it does not specifically isolate the effects of oregano itself. Thus, while carvacrol's influence is significant, we must remain cautious about broadening these results to the wider effects of oregano as a whole.
Read More
8
We investigated how the methanol extract of Origanum syriacum, commonly known as oregano, affects lung cancer cells, particularly A549 cells. Our study aimed to understand whether this natural extract could suppress cell growth and induce programmed cell death, or apoptosis, which is crucial in targeting cancer cells.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
Read More
8
We aimed to investigate how thyme extracts, particularly from oregano, can help combat oxidative DNA damage in lung cancer cells. In our study, we focused on different thyme products, including standard compounds like carvacrol and thymol, as well as extracts and oils derived from thyme. The effectiveness of these antioxidants was tested on malignant lung cells known as A549.
Our experiments included assessing the antioxidant capacity of these thyme extracts and analyzing their components. We discovered that the antioxidant capacity of thyme oil was significant, with measured effectiveness comparable to standard antioxidants. The crucial finding was that thymoquinone emerged as the most potent defender against oxidative damage, while the water-methanol extract of thyme also showed promise as a protective agent.
Furthermore, we extended our research to healthy lung cells, revealing that both thymoquinone and the thyme water-methanol extract provided protection against DNA damage in these cells too. Overall, our findings suggest the potential of oregano-derived thyme extracts in preserving DNA integrity and possibly aiding in lung cancer prevention and treatment.
Our experiments included assessing the antioxidant capacity of these thyme extracts and analyzing their components. We discovered that the antioxidant capacity of thyme oil was significant, with measured effectiveness comparable to standard antioxidants. The crucial finding was that thymoquinone emerged as the most potent defender against oxidative damage, while the water-methanol extract of thyme also showed promise as a protective agent.
Furthermore, we extended our research to healthy lung cells, revealing that both thymoquinone and the thyme water-methanol extract provided protection against DNA damage in these cells too. Overall, our findings suggest the potential of oregano-derived thyme extracts in preserving DNA integrity and possibly aiding in lung cancer prevention and treatment.
Read More
8
We set out to investigate how oregano, specifically its extract, impacts lung cancer cells. Using a method that combined the aqueous extract of Origanum vulgare—commonly known as oregano—with silver nitrate, we were able to create silver nanoparticles. These nanoparticles were carefully analyzed using various scientific techniques, revealing that they had a spherical shape and an average size of about 136 nanometers.
The findings highlighted that these green synthesized silver nanoparticles were effective in inhibiting certain human pathogens. More importantly, they showed a dose-dependent response against the A549 cell line, a common model for studying lung cancer. Specifically, we noted an LD50 value of 100 micrograms per milliliter, indicating that the nanoparticles from oregano extract have promising anticancer properties.
Overall, this study showcases that oregano not only has potential in combating bacteria but may also play a role in the fight against lung cancer. This opens up exciting avenues for future research on natural remedies in cancer treatment.
The findings highlighted that these green synthesized silver nanoparticles were effective in inhibiting certain human pathogens. More importantly, they showed a dose-dependent response against the A549 cell line, a common model for studying lung cancer. Specifically, we noted an LD50 value of 100 micrograms per milliliter, indicating that the nanoparticles from oregano extract have promising anticancer properties.
Overall, this study showcases that oregano not only has potential in combating bacteria but may also play a role in the fight against lung cancer. This opens up exciting avenues for future research on natural remedies in cancer treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
6
Good protective effects
4 people found this helpful
Strong and concentrated! Exceptional quality! The active ingredient is potent; I take one capsule twice daily after meals. The flavour of oregano is robust. This supplement is intended to regulate intestinal flora, and I believe it also has a beneficial effect on the lungs, offering protection against inflammation. I highly recommend it. The capsules are small in size.
Read More
7.5
Reduces lung infection
42 people found this helpful
Fun fact: The ancient Greeks used Oregano oil as an antidote! The manufacturer recommends 1 softgel 1–3 times daily. Oregano is an effective natural antibiotic. During my illness, my husband and I took numerous IHERB supplements, but Oregano twice daily was essential! Combined with other treatments, it prevented the virus from infecting my lungs, resulting in a "mild form" of the disease. It can sometimes cause belching, but that doesn't happen constantly. Even children can swallow the small gelatine capsules. I suggest starting Oregano in autumn or winter; it has helped our family immensely!
Read More
7.5
Skin and digestion improved
18 people found this helpful
Extraordinary!!! High-quality products from NOW FOODS contain oregano, ginger, and fennel oils. I’ve shared this with my 12-year-old. This oil has antiviral, antifungal, antibacterial, anti-cancer, and anti-inflammatory properties. We began taking oregano oil together as a family due to the recent wave of coronavirus. The kids have improved digestion, skin condition, and feel lighter.
Read More
7
Stuffy nose prevention
Great for clearing up respiratory issues! After recovering from long covid, my lungs became sensitive to colds. I started taking this oregano oil a couple of times daily when I felt stuffy or a cough coming on. It helps prevent my symptoms from worsening, and I’m a big fan—I don't ever want to run out.
Read More
Frequently Asked Questions
7
Stuffy nose prevention
Great for clearing up respiratory issues! After recovering from long covid, my lungs became sensitive to colds. I started taking this oregano oil a couple of times daily when I felt stuffy or a cough coming on. It helps prevent my symptoms from worsening, and I’m a big fan—I don't ever want to run out.
7.5
Reduces lung infection
42 people found this helpful
Fun fact: The ancient Greeks used Oregano oil as an antidote! The manufacturer recommends 1 softgel 1–3 times daily. Oregano is an effective natural antibiotic. During my illness, my husband and I took numerous IHERB supplements, but Oregano twice daily was essential! Combined with other treatments, it prevented the virus from infecting my lungs, resulting in a "mild form" of the disease. It can sometimes cause belching, but that doesn't happen constantly. Even children can swallow the small gelatine capsules. I suggest starting Oregano in autumn or winter; it has helped our family immensely!
6
Good protective effects
4 people found this helpful
Strong and concentrated! Exceptional quality! The active ingredient is potent; I take one capsule twice daily after meals. The flavour of oregano is robust. This supplement is intended to regulate intestinal flora, and I believe it also has a beneficial effect on the lungs, offering protection against inflammation. I highly recommend it. The capsules are small in size.
7.5
Skin and digestion improved
18 people found this helpful
Extraordinary!!! High-quality products from NOW FOODS contain oregano, ginger, and fennel oils. I’ve shared this with my 12-year-old. This oil has antiviral, antifungal, antibacterial, anti-cancer, and anti-inflammatory properties. We began taking oregano oil together as a family due to the recent wave of coronavirus. The kids have improved digestion, skin condition, and feel lighter.
8
We investigated how the methanol extract of Origanum syriacum, commonly known as oregano, affects lung cancer cells, particularly A549 cells. Our study aimed to understand whether this natural extract could suppress cell growth and induce programmed cell death, or apoptosis, which is crucial in targeting cancer cells.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
We first checked the cell viability of A549 cells after exposure to various concentrations of oregano extract. Our observations revealed that higher concentrations led to a notable decline in cell growth and prompted significant changes in cell structure. At the 200 mg/ml dose, many cell membranes appeared to break down, indicating a strong response to the treatment.
Moreover, at a lower dose of 25 μg/ml, we noted an increase in Bax expression—a protein that promotes apoptosis—as well as a rise in late apoptotic cells. We also identified key phenolic compounds like vanillic acid and luteolin in the extract, which may contribute to its beneficial effects.
Overall, the evidence suggests that oregano extract can effectively block lung cancer cell growth and induce apoptosis, showcasing its potential as a natural therapeutic agent.
9
We explored the anticancer potential of Origanum majorana essential oil (OMEO) on non-small cell lung cancer (NSCLC) using two significant human cancer cell lines: A549 and LNM35. Through a series of pre-clinical experiments, we observed that OMEO significantly reduced the viability of these cancer cells and inhibited their colony growth in a way that depends on the concentration used.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
Additionally, we noted that OMEO slowed the growth of tumors derived from A549 and LNM35 cells both in chick embryos and in nude mice models. Our findings also revealed that OMEO effectively decreased cancer cell migration and invasion, alongside reducing the incidence and growth of lymph node metastases in mice. Remarkably, treatment with OMEO over three months did not interfere with the normal functions of blood, kidneys, or liver.
Overall, our study highlights OMEO as a promising and safe anticancer option, particularly for those facing the challenges of lung cancer.
9
Carvacrol inhibits lung cancer growth
We explored how carvacrol, the main component found in oregano, impacts a specific type of lung cancer known as non-small cell lung cancer (NSCLC), particularly using the A549 cell line for our experiments. Carvacrol is well-known for its various health benefits, which include antibacterial and antioxidant effects. In our study, we incubated A549 cells with different concentrations of carvacrol and observed its effects on cell health and growth.
Our observations revealed that as we increased the dosage of carvacrol, the number of living cells decreased significantly. Not only did we notice a reduction in cell count, but we also saw marked changes in cell shape and structure, indicating physical degeneration. Under light microscopy, the treated cells demonstrated signs of distress, such as detachment from the surface, rounding, and irregular shapes.
The findings show that carvacrol can effectively inhibit cell growth in lung cancer cells. While this study highlights the potential of carvacrol derived from oregano in combating NSCLC, we should note that it does not specifically isolate the effects of oregano itself. Thus, while carvacrol's influence is significant, we must remain cautious about broadening these results to the wider effects of oregano as a whole.
Our observations revealed that as we increased the dosage of carvacrol, the number of living cells decreased significantly. Not only did we notice a reduction in cell count, but we also saw marked changes in cell shape and structure, indicating physical degeneration. Under light microscopy, the treated cells demonstrated signs of distress, such as detachment from the surface, rounding, and irregular shapes.
The findings show that carvacrol can effectively inhibit cell growth in lung cancer cells. While this study highlights the potential of carvacrol derived from oregano in combating NSCLC, we should note that it does not specifically isolate the effects of oregano itself. Thus, while carvacrol's influence is significant, we must remain cautious about broadening these results to the wider effects of oregano as a whole.
4
Oregano extracts show limited cancer activity
We tested several extracts from Origanum dictamnus, a plant native to Crete, to explore their effects on lung cancer. In our analysis, we focused on two cell lines: P388, a murine leukemia model, and NSCLC-N6, which represents a type of non-small cell lung cancer. Both extracts, including a specific compound called ursolic acid, showed some level of cytotoxic activity in lab tests.
We also took our investigation a step further by looking at the effects of ursolic acid in live models. When administered to mice with ascitic leukemia, the compound demonstrated only marginal antileukemic activity at a dose of 50 mg/kg. This indicates that while oregano extracts have potential, the significant impacts on lung cancer specifically are yet to be fully realized or proven.
Overall, our findings suggest that while the cytotoxic effects are promising, they do not indicate a robust treatment option for lung cancer at this time.
We also took our investigation a step further by looking at the effects of ursolic acid in live models. When administered to mice with ascitic leukemia, the compound demonstrated only marginal antileukemic activity at a dose of 50 mg/kg. This indicates that while oregano extracts have potential, the significant impacts on lung cancer specifically are yet to be fully realized or proven.
Overall, our findings suggest that while the cytotoxic effects are promising, they do not indicate a robust treatment option for lung cancer at this time.
References
- Yumrutaş Ö, Yumrutaş P, Pehlivan M, Korkmaz M, Kahraman D. Origanum syriacum Induces Apoptosis in Lung Cancer Cells by Altering the Ratio of Bax/Bcl2. Anticancer Agents Med Chem. 2025. 10.2174/0118715206333509241112060647
- Arafat K, Sulaiman S, Al-Azawi AM, Yasin J, Sugathan S, et al. Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo. Biomed Pharmacother. 2022;155:113762. 10.1016/j.biopha.2022.113762
- Aybastıer Ö, Dawbaa S, Demir C, Akgün O, Ulukaya E, et al. Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage. Mutat Res. 2018;808:1. 10.1016/j.mrfmmm.2018.01.004
- Sankar R, Karthik A, Prabu A, Karthik S, Shivashangari KS, et al. Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity. Colloids Surf B Biointerfaces. 2013;108:80. 10.1016/j.colsurfb.2013.02.033
- Koparal AT, Zeytinoglu M. Effects of Carvacrol on a Human Non-Small Cell Lung Cancer (NSCLC) Cell Line, A549. Cytotechnology. 2003;43:149.
- Chinou I, Liolios C, Moreau D, Roussakis C. Cytotoxic activity of Origanum dictamnus. Fitoterapia. 2007;78:342.
